Saltar al contenido
Merck
Todas las fotos(1)

Documentos

SCP0212

Sigma-Aldrich

PKA Substrate

≥95% (HPLC), lyophilized

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C39H74N20O12
Peso molecular:
1015.13
UNSPSC Code:
12352204
NACRES:
NA.32

product name

PKA Substrate,

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥60%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ser-Ile-NH2

General description

cAMP-dependent protein kinase (PKA) Substrate (GRTGRRNSI-NH2) is a nine amino acid phosphorylatable substrate of cyclic adenosine monophosphate (cAMP)-dependent protein kinase.

application

cAMP-dependent protein kinase (PKA) Substrate has been used as a peptide substrate for Plasmodium cyclic guanosine monophosphate (GMP)-dependent protein kinase in enzymatic assay and inhibition assay. It has also been used as a positive control in the in vitro protein kinase A (PKA) phosphorylation assay.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Jacqueline B Pierce et al.
Eukaryotic cell, 13(2), 209-230 (2013-12-04)
The two main signal transduction mechanisms that allow eukaryotes to sense and respond to changes in glucose availability in the environment are the cyclic AMP (cAMP)/protein kinase A (PKA) and AMP-activated protein kinase (AMPK)/Snf1 kinase-dependent pathways. Previous studies have shown
Q Ni et al.
Protein science : a publication of the Protein Society, 9(9), 1818-1827 (2000-10-25)
The binding of the methylanthraniloyl derivatives of ATP (mant-ATP), ADP (mant-ADP), 2'deoxyATP (mant-2'deoxyATP), and 3'deoxyATP (mant-3'deoxyATP) to the catalytic subunit of protein kinase A was studied to gain insights into the mechanism of nucleotide binding. The binding of the mant
Michael J Moore et al.
The Journal of biological chemistry, 278(12), 10613-10618 (2002-12-25)
For optimal activity the catalytic subunit of cAMP-dependent protein kinase requires a phosphate on Thr-197. This phosphate anchors the activation loop in the proper conformation and contributes to catalytic efficiency by enhancing the phosphoryl transfer rate and increasing the affinity
Maria Penzo et al.
Scientific reports, 9(1), 7005-7005 (2019-05-09)
Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental stages. An imidazopyridine PKG inhibitor scaffold
Manu Vanaerschot et al.
Cell chemical biology, 27(7), 806-816 (2020-05-04)
The search for antimalarial chemotypes with modes of action unrelated to existing drugs has intensified with the recent failure of first-line therapies across Southeast Asia. Here, we show that the trisubstituted imidazole MMV030084 potently inhibits hepatocyte invasion by Plasmodium sporozoites

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico