SBR00121

Amphotericin B water soluble

from semisynthetic, powder

• Sinónimos: AmB, Amphotericin
• Fórmula empírica (notación de Hill): C₅₁H₈₂N₂O₁₉
• Peso molecular: 1027.20
• Código UNSPSC: 51302401

Propiedades

• origen biológico: fermentation/recombinant; semisynthetic
• Nivel de calidad: 200
• Ensayo: ≥90% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: protect from light
• color: light yellow to very dark yellow, to very dark brown
• Modo de acción: cell membrane | interferes
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• idoneidad: fungi; yeasts
• cadena SMILES: C[C@@H](O1)[C@@H](O)[C@H]([NH3+])[C@H](O)[C@]1([H])O[C@H](C[C@@]2([H])[C@@H]([C@@H](O)C[C@@](O2)(O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C3)C(NCCO)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC3=O.CC([O-])=O
• InChI: 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• Clave InChI: APKFDSVGJQXUKY-INPOYWNPSA-N

Descripción

Descripción general

Amphotericin B is a polyene antifungal antibiotic which has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Amphotericin B water soluble is a synthetic derivative of AmB that preserves the antifungal activity but is highly miscible in water up to 100 mg/mL.

Acciones bioquímicas o fisiológicas

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. Antimicrobial spectrum: Includes fungi and yeast It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium. Amphotericin B is most effective against fungi and yeast.

Características y beneficios

Easily soluble in water up to 100mg/mL
Animal component free
Tested for cell toxicity
Can be 0.2µm filtered

Nota de preparación

Amphotericin B water soluble can be directly dissolved in the media to a working concentration of 2.5 mg/L.

Otras notas

Product is sensitive to light.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H372
• Consejos de prudencia: P260 - P264 - P270 - P314 - P501
• Clasificaciones de peligro: STOT RE 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable