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SAB5201735

Sigma-Aldrich

Monoclonal Anti-Tcp1 Alpha - Atto 390 antibody produced in rat

clone 23c, purified immunoglobulin

Sinónimos:

Anti-AI528772, Anti-Ccta, Anti-Tric, Anti-p63

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rat

Quality Level

conjugate

Atto 390 conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

23c, monoclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt 60 kDa

species reactivity

mouse, human, dog, rabbit, rat, hamster, bovine, sheep

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2c

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Tcp1(21454)

General description

Tcp1 (t-complex protein ) is a chaperonin and a ATPase complex that encodes a chaperonin, localized to the cytosol.

Immunogen

Purified recombinant mouse TCP1 alpha construct encoding the C-terminal half of the 1.8 kb full-length Tcp 1b gene expressed in E. coli. Detects the COOH group.

Biochem/physiol Actions

Tcp1 (t-complex protein) is involved in protein folding mechanism of essential proteins such as actins, tubulin, cyclin E, α-transducin and von Hippel Lindau protein. Tcp1 participates in synthesis of proteins that make up the cytoskeleton and thus involved in cellular processes such as chromosome segregation, cell migration, and intracellular transport. Increased TCP1 gene expression is observed in cancer and upregulation elevates with the disease progression.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro.
Svanstrom A and Grantham J
Cell Stress & Chaperones, 21(1), 55-62 (2016)
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington?s disease.
Zhao X, et al.
Proceedings of the National Academy of Sciences of the USA, 113(38), E5655-E5664 (2016)
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Jiang X, et al.
Oncotarget, 6(39), 42105-42105 (2015)
Satyabrata Sinha et al.
Investigative ophthalmology & visual science, 55(6), 3775-3785 (2014-05-24)
While some evidence suggests an essential role for the chaperonin containing t-complex protein 1 (CCT) in ciliogenesis, this function remains poorly understood mechanistically. We used transgenic mice, previously generated in our lab, and characterized by a genetically-induced suppression of CCT

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