SAB4700562

Monoclonal Anti-Cd86-FITC antibody produced in rat

clone GL-1, purified immunoglobulin, buffered aqueous solution

• Código UNSPSC: 12352203
• NACRES: NA.44

Propiedades

• origen biológico: rat
• conjugado: FITC conjugate
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: GL-1, monoclonal
• Formulario: buffered aqueous solution
• reactividad de especies: mouse
• concentración: 0.5 mg/mL
• técnicas: flow cytometry: suitable
• isotipo: IgG2a
• Nº de acceso NCBI: NM_019388.3
• Nº de acceso UniProt: P42082
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• Información sobre el gen: mouse ... Cd86(12524)

Descripción

Descripción general

Cluster of differentiation 86 (CD86), also known as B7-2, is encoded by the gene mapped to human chromosome 3q13.33. CD86 is a co-stimulatory molecule expressed on various immune cells. The encoded protein belongs to the immunoglobulin (Ig) superfamily.

The rat monoclonal antibody GL-1 reacts with CD86 (B7-2), a 70-80 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

Inmunógeno

LPS-activated CBA/Cs mouse splenic B cells

Aplicación

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Acciones bioquímicas o fisiológicas

Cluster of differentiation 86 (CD86) plays a vital role in immune responses. Mutations in the gene leads to the development of pneumonia-induced sepsis by downregulating CD86 gene expression in monocytes. Additionally, genetic variation in the gene increases the risk of susceptibility to colorectal cancer.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable