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Key Documents

SAB4700313

Sigma-Aldrich

Monoclonal Anti-HLA-G-Biotin antibody produced in mouse

clone MEM-G/9, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

biotin conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MEM-G/9, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... HLA-G(3135)

General description

The antibody MEM-G/9 reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody MEM-G/9 is standard reagent thoroughly validated during 3rd International Conference on HLA-G (Paris, 2003).
Histocompatibility leukocyte antigen–G (HLA-G), a naturally occurring immunosuppressive molecule, is located on human chromosome 6p21. HLA-G gene codes for a tolerogenic protein.

Immunogen

Recombinant human HLA-G refolded with beta2-microglobulin and peptide

Application

The reagent is designed for Flow Cytometry analysis of cells expressing HLA-G molecule on the cell surface using a 1:1000 dilution. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Histocompatibility leukocyte antigen–G (HLA-G) plays an important role in preventing the activities of natural killer (NK) cell and inducing immune escape. It has the ability to block immune competent cells and innate and adaptive immune system. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue.
Wei X and Orr HT
Human immunology, 29(2), 131-142 (1990)
Human Leukocyte Antigen-G Inhibits the Anti-Tumor Effect of Natural Killer Cells via Immunoglobulin-Like Transcript 2 in Gastric Cancer.
Wan R, et al.
Cellular Physiology and Biochemistry, 44(5), 1828-1841 (2017)
HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia.
Caocci G, et al.
Leukemia Research, 61, 1-5 (2017)
Recipient HLA-G+ 3142 CC genotype and concentrations of soluble HLA-G impact on occurrence of CMV infection after living-donor kidney transplantation.
Guberina H, et al.
International Journal of Molecular Sciences, 18(11), 2338-2338 (2017)

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