Arrestin 1 (ARRB1) is also termed as β-arrestin-1. This is a cytoplasmic adaptor protein located on human chromosome 11q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412.
Immunogen Range: 369-418
Biochem/physiol Actions
Arrestin 1 (ARRB1) participates in DNA damage accumulation and cell apoptosis. Deletion of ARRB1 blocks DDR (DNA damage response) pathway activation. During hypoxia, ARRB1 controls breast cancer cell survival with the help of HIF-1 transcription factor. This gene can act as a scaffold and an adaptor in receptor endocytosis and signal transduction.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13
Calabrese G, et al.
Genomics, 24(1), 169-171 (1994)
?-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor
Qiu C, et al.
International Journal of Clinical and Experimental Pathology, 8(4), 3785-3793 (2015)
ARRB1/?-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia
Wang P, et al.
Autophagy, 10(9), 1535-1548 (2014)
ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response
Shen H, et al.
Oncology Reports, 37(2), 761-767 (2017)
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