SAB4502958

Anti-TGF β Receptor I antibody produced in rabbit

affinity isolated antibody

• Sinónimos: ADRB2, ALK-5, Activin receptor-like kinase 5, ESK2, SKR4
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 55 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI accession no.: P36897
• UniProt accession no.: P36897
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TGFBR1(7046)

Descripción

General description

Anti-TGF β Receptor I Antibody detects endogenous levels of total TGF β Receptor I protein.

Transforming growth factor β receptor-1 (TGF-β R1), also known as activin receptor-like kinase 5 (ALK5) receptor, is encoded by the gene mapped to human chromosome 9q22.3. It is widely expressed in human tissues.

Immunogen

The antiserum was produced against synthesized peptide derived from human TGF beta Receptor I.

Immunogen Range: 131-180

Application

Anti-TGF β Receptor I antibody produced in rabbit has been used for:

• Immunohistochemistry[1]
• Western blotting[2]
• Immunofluroscence[2]

Biochem/physiol Actions

Transforming growth factor β receptor-1 (TGF-β R1) plays an essential role in carbon nanotube-induced fibrogenesis by enhancing collagen production in lung fibroblasts. TβR-dependent signals plays a crucial role in cell growth and differentiation, and polymorphism or mutation of TGF-β R1 leads to head and neck cancer. Activin receptor-like kinase 5 (ALK5) or TGF-β R1 promotes the phosphorylation of small mothers against decapentaplegic (Smad) 2 and Smad3. Activated ALK5 inhibits migration and proliferation of endothelial cells (ECs). ALK1 acts as an antagonist for ALK5/Smad signaling. Mutation of TGF-β R1 can also cause autosomal dominant skin cancer called multiple self-healing squamous epithelioma (MSSE) or Ferguson-Smith disease (FSD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable