SAB4300246

Anti-phospho-SHC1 (pTyr⁴²⁷) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-FLJ26504 antibody produced in rabbit, Anti-SHC (Src homology 2 domain containing) transforming protein 1 antibody produced in rabbit, Anti-SHC antibody produced in rabbit, Anti-SHCA antibody produced in rabbit
• MDL number: MFCD01634176
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~46 kDa; ~52 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (P-S-YP-V-N
• NCBI accession no.: NP_001123512.1
• UniProt accession no.: P29353
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr427)
• Gene Information: human ... SHC1(6464)

Descripción

Immunogen

Peptide sequence around phosphorylation site of tyrosine 427 (P-S-Y(p)-V-N, according to the protein SHC1.

Features and Benefits

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Target description

Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable