SAB4300200

Anti-phospho-MAPK14 (pThr¹⁸⁰) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-CSBP1 antibody produced in rabbit, Anti-CSBP2 antibody produced in rabbit, Anti-CSPB1 antibody produced in rabbit, Anti-EXIP antibody produced in rabbit, Anti-mitogen-activated protein kinase 14 antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~43 kDa
• species reactivity: rat, human, mouse
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (E-M-TP-G-Y)
• NCBI accession no.: NP_001306.1
• UniProt accession no.: Q16539
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr180)
• Gene Information: human ... MAPK14(1432)

Descripción

Immunogen

Peptide sequence around phosphorylation site of threonine 180 (E-M-T(p)-G-Y ), according to the protein MAPK14.

Features and Benefits

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Target description

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable