Porphyromonas gingivalis (Lipopolysaccharides (LPS) from whole extract)
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
immunoblotting: 1:50,000-1:100,000 using dead Porphyromonas gingivalis bacteria indirect ELISA: 1:20,000-1:40,000 using Porphyromonas gingivalis LPS for coating.
Porphyromonas gingivalis is a nonmotile, Gram-negative, rod-shaped, anaerobic pathogenic bacterium, belongs to the Porphyromonadaceae family, phylum Bacteroidetes class.1 P. gingivalis is involved in a number of pathogenic mechanisms including tissue colonization and destruction, as well as host defense activation. This bacterium is known for the ability to colonize at the oral cavity which consider a major public health issue. It can also be found in lung, liver, or splenic abscesses and the upper gastrointestinal tract and is related to atherosclerotic plaque disease, Cardiovascular diseases, Adverse pregnancy outcomes, Rheumatoid arthritis (RA), Meningitis or brain abscesses and Alzheimer′s disease. P. gingivalis ability to aggregate in biofilms is considered a significant health risk by elevated resistance to host defense mechanisms and decreased susceptibility to conventional antimicrobials agents. P. gingivalis have several potential secreted and membranal virulence factors such as Gingipains proteolytic complex (Rgp and Kgp) which degrade various host proteins, Fimbriae (FimA and Mfa1) responsible for attachment of bacterial cells to host cell surfaces and Haemagglutinins (HagA) involved in adhesion and invasion of host cells.
Application
Anti-Porphyromonas gingivalis antibody recognizes P. gingivalis whole extract and P. gingivalis Lipopolysaccharides (LPS), the antibody has no cross reactivity with P. mirabilis or E. coli. The antibody may be used in various immunochemical techniques including Immunoblotting and ELISA. Detection of the P. gingivalis bands by Immunoblotting is specifically inhibited by the immunogen.
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
Other Notes
Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Disclaimer
This product is for R&D use only, not for drug, household, or other uses.
Frontiers in aging neuroscience, 9, 398-398 (2017-12-19)
Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer's disease (AD). However, the explanation of how periodontitis can lead to dementia remains unclear. A working hypothesis links extrinsic inflammation as a secondary cause
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