SAB4200630

Monoclonal Anti-SFRP1 antibody produced in mouse

clone FRP148, purified from hybridoma cell culture

• Sinónimos: Anti-FRP, Anti-FRP-1, Anti-FrzA, Anti-Secreted apoptosis-related protein 2 (SARP2), Anti-secreted frizzled-related protein 1
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: mouse
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: FRP148, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~35 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): flow cytometry: 10-20 μg/test using using WI-38 cells.; immunoblotting: 0.025-0.05 μg/mL using using whole extracts of WI-38 cells.
• isotype: IgG2a
• UniProt accession no.: Q8N474
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SFRP1(6422)

Descripción

General description

The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.

Immunogen

synthetic peptide corresponding to a sequence at the N-terminal region of human SFRP1.

Biochem/physiol Actions

Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable