SAB3300047

Monoclonal Anti-TUBB3 antibody produced in mouse

clone 5H2, purified immunoglobulin, buffered aqueous glycerol solution

• Sinónimos: Anti-β-4, Anti-MC1R, Anti-TUBB4
• UNSPSC Code: 12352203

Propiedades

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 5H2, monoclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen 50.3 kDa
• species reactivity: human
• technique(s): western blot: suitable
• NCBI accession no.: NM_006086
• UniProt accession no.: Q13509
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... TUBB3(10381)

Descripción

Immunogen

Recombinant protein expressed in E. coli corresponding to amino acids 1-150 of human TUBB3

Target description

Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement, and the cytoskeleton. Except in the simplest eukaryotes, tubulin exists in all cells as a mixture of similar, but not identical, sets of alpha and beta tubulin polypeptides. Within either set of polypeptides, individual subunits diverge from each other (both within and across species) at less than 10% of the amino acid positions. The most extreme diversity is localized to the 15 residues of the carboxy terminal. For β-tubulin five evolutionarily conserved isotype clones have been identified. These are almost totally conserved in the subunits utilized in the same cell types of different species, with the exception of the hematopoietic β-tubulin which is the most highly divergent in sequence and is not conserved between species. Research has been centered around the hypothesis that these beta tubulin isotypes contribute to unique functional properties. It has been reported that the different isotypes of tubulin differ from each other in their ability to polymerize into microtubules.

Physical form

Solution in phosphate buffered saline containing 1% bovine serum albumin, 50% glycerol, and 0.02% sodium azide.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable