Thyroid peroxidase (TPO) is a membrane-bound, glycosylated, heme-containing peroxidase. It is encoded by the gene mapped to human chromosome 2p25.3. The encoded protein is a member of the human peroxidases family. TPO is a ~100 kDa protein with 933-amino acids. Mature TPO is characterized with a short transmembrane and cytoplasmic regions, as well as a dominant ectodomain, containing MPO-like, complement control protein (CCP)-like and epidermal growth factor (EGF)-like domains.
Inmunógeno
Peptide with sequence C-TRHVIQVSNEVVTDD, from the internal region of the protein sequence according toNP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1
Acciones bioquímicas o fisiológicas
Thyroid peroxidase (TPO) is involved in the biosynthesis of thyroid hormones T3 and T4. It catalyzes the oxidation of the inorganic iodide and coupling of iodinated tyrosine to produce thyroxine and triiodothyronine. Mutation in the gene increases the risk of susceptibility to autoimmune thyroiditis in patients with allergic rhinitis and asthma. Genetic deficiency of TPO is associated with the development of congenital hypothyroidism.
Características y beneficios
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Forma física
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Serum Anti-TPO and TPO Gene Polymorphism as a Predictive Factor for Hidden Autoimmune Thyroiditis in Patient with Bronchial Asthma and Allergic Rhinitis.
El RS, et al.
The Egyptian Journal of Immunology / Egyptian Association of Immunologists, 23(1), 77-86 (2016)
Thyroid peroxidase (TPO) expressed in thyroid and breast tissues shows similar antigenic properties.
Godlewska M, et al.
PLoS ONE, 12(6) (2017)
Triallelic patterns in STR loci used for paternity analysis: Evidence for a duplication in chromosome 2 containing the TPOX STR locus
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