Flotillin 1 (FLOT1) is an integral membrane protein and a component of lipid rafts. This estrogen responsive gene is localized on human chromosome 6p21.33.
Inmunógeno
FLOT1 (NP_005794.1, 126 a.a. ~ 225 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Flotillin 1 (FLOT1) has a role in endocytosis. It also functions in growth factor signaling and activates mitogen-activated protein kinase signaling. The protein has been associated with tumor progression and is expressed in many cancers.
Forma física
Clear solution
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Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade.
Winship AL
Cancer Investigation (2016)
Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-? signaling in nasopharyngeal carcinoma.
Cao S
Oncotarget (2016)
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
Regine Bergholdt
Genome Biology (2007)
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