SAB1304901

ANTI-CCL22 (CENTER) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: C-C motif chemokine 22, CCL22, MDC, SCYA22
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• antibody form: IgG fraction of antiserum
• Quality Level: 100
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 10625 Da
• species reactivity: human
• technique(s): western blot: 1:250-1:500
• NCBI accession no.: NP_002981.2
• UniProt accession no.: O00626
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CCL22(6367)

Descripción

General description

Macrophage-derived chemokine (MDC) is also known as C-C motif chemokine ligand 22 (CCL22). It is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated natural killer (NK) cells and cluster of differentiation 4 (CD4) T cells. The gene encoding it is localized on human chromosome 16. Recombinant human MDC is an 8.0kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Biochem/physiol Actions

Macrophage-derived chemokine (MDC) signals through the C-C chemokine receptor type 4 (CCR4). It chemo-attracts monocytes, dendritic cells and natural killer (NK) cells and aids in their function. The protein exerts human immunodeficiency virus (HIV) suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. It is expressed in various cancers and is involved in recruitment of regulatory T cells (Treg) within a tumor.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable