S9572
Anti-Sonic Hedgehog peptide (N-terminal) antibody produced in goat
affinity isolated antibody, lyophilized powder
Sinónimos:
Anti-Dsh, Anti-Hhg1, Anti-Hx, Anti-Shh
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About This Item
Código UNSPSC:
51111800
NACRES:
NA.41
origen biológico
goat
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
mouse
técnicas
immunohistochemistry: 15 μg/mL
western blot: 0.1-0.2 μg/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Shh(20423)
Descripción general
The Hedgehog (Hh) family of secreted proteins consists of sonic hedgehog (Shh), desert hedgehog (Dhh) and Indian hedgehog (Ihh). The Hh signaling regulates cell migration and tissue construction during embryogenesis and reconstruction in adults. Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, γ catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb and axon guidance factors during the development of brain and nervous system. Hedgehog signaling has been implicated in childhood tumors of pancreas, liver, thyroid, gastrointestinal tract, neuroblastomas and medulloblastomas
Anti-Sonic Hedgehog Peptide (N-terminal) recognizes mouse Sonic Hedgehog N-terminal peptide.
Anti-Sonic Hedgehog Peptide (N-terminal) recognizes mouse Sonic Hedgehog N-terminal peptide.
Inmunógeno
purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog N-terminal peptide.
Aplicación
Anti-Sonic Hedgehog Peptide (N-terminal) can be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For immunohistochemistry, a working concentration of 15 μg/ml is recommended.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Role of Sonic hedgehog signaling pathway in neuroblastoma development
Shahi MH et al
Biol. Med., 1, Rev 2-Rev 2 (2009)
X Wu et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(1), G295-G306 (2007-11-23)
Saccharomyces boulardii has received increasing attention as a probiotic effective in the prevention and treatment of infectious and inflammatory bowel diseases. The aim of this study was to examine the ameliorating effects of S. boulardii on Citrobacter rodentium colitis in
Gijs R van den Brink
Physiological reviews, 87(4), 1343-1375 (2007-10-12)
The Hedgehog family of secreted morphogenetic proteins acts through a complex evolutionary conserved signaling pathway to regulate patterning events during development and in the adult organism. In this review I discuss the role of Hedgehog signaling in the development, postnatal
Fergal C Kelleher
Carcinogenesis, 32(4), 445-451 (2010-12-28)
To conduct a systematic review of the role that the hedgehog signaling pathway has in pancreatic cancer tumorigenesis. PubMed search (2000-2010) and literature based references. Firstly, in 2009 a genetic analysis of pancreatic cancers found that a core set of
Shohreh F Farzan et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(4), G844-G849 (2008-02-02)
The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given
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