The stability of this material in solution has not been determined. However, external sources report that stock solutions prepared in DMSO may be stored in aliquots at -20°C for up to three months. Avoid repeated freeze/thaw cycles. This information has not been validated.
S4696
SB-505124 hydrochloride hydrate
≥98% (HPLC)
Sinónimos:
2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride hydrate
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5 MG
MXP 6,822.00
25 MG
MXP 19,887.00
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5 MG
MXP 6,822.00
25 MG
MXP 19,887.00
About This Item
Fórmula empírica (notación de Hill):
C20H21N3O2 · xHCl · yH2O
Número de CAS:
Peso molecular:
335.40 (anhydrous free base basis)
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
powder
condiciones de almacenamiento
desiccated
color
yellow
solubilidad
DMSO: >10 mg/mL
H2O: insoluble
emisor
GlaxoSmithKline
temp. de almacenamiento
2-8°C
cadena SMILES
O.Cl.Cc1cccc(n1)-c2[nH]c(nc2-c3ccc4OCOc4c3)C(C)(C)C
InChI
1S/C20H21N3O2.ClH.H2O/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;;/h5-10H,11H2,1-4H3,(H,22,23);1H;1H2
Clave InChI
DIDCCMVWCVRTNB-UHFFFAOYSA-N
Aplicación
SB-505124 hydrochloride hydrate was used to study the role of TGF-β pathway in development and differentiation studies.3,4
Acciones bioquímicas o fisiológicas
SB-505124 is an inhibitor of activin receptor-like kinase (ALK) 5, also known as transforming growth factor-α type I receptor kinase, with an IC50 of 47 ± 5 nM.
SB-505124 selectively inhibits TGF-β type I receptors, activin receptor-like kinases (ALK) 4, 5 and 7. It inhibits ALK4-, 5- and 7-mediated activation of Smad2, Smad3 and MAPK pathway induced by TGF-β.1 SB-505124 inhibits the human fibroblast trans-differentiation induced by the co-culture with Esophageal squamous cell carcinoma.2
Características y beneficios
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órganos de actuación
Respiratory system
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Gloves
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Reconstructing the tempo at which biodiversity arose is a fundamental goal of evolutionary biologists, yet the relative merits of evolutionary-rate estimates are debated based on whether they are derived from the fossil record or time-calibrated phylogenies (timetrees) of living species.
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how long is SB-505124 stable for when stored as a 200mM DMSO stock at -20C?
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