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S3884

Sigma-Aldrich

Sauvagine

≥97% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C202H346N56O63S
Número de CAS:
74434-59-6
Peso molecular:
4599.31
Número MDL:
MFCD00081983
Código UNSPSC:
12352200
NACRES:
NA.32

Ensayo

≥97% (HPLC)

temp. de almacenamiento

−20°C

Clave InChI

ILCVKEBXPLEGOY-ZLFMSJRASA-N

Amino Acid Sequence

Glp-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2

Descripción general

Sauvagine is a polypeptide derived from the frog skin. It belongs to the CRH (corticotropin releasing factor) family. Sauvagine is made of 40 amino acids.[1] It may also be found in the brain of mammals.[2]

Acciones bioquímicas o fisiológicas

A peptide related to CRF and urotensin 1 that was first isolated from the skin of the frog Phyllomedusa sauvagei. Potent releaser of ACTH and β-endorphin from the anterior pituitary.
Sauvagine helps to liberate ACTH (adrenocorticotropic hormone) from the pituitary cells of rat.[1] It has several important functions in the cardiovascular, endocrine and renal systems.[2]

Otras notas

Lyophilized from 0.1% TFA in H2O

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
074M4831V
119K4836
047K4834
017K4861
016K4758

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Satoko Ise et al.
Brain research, 1234, 59-65 (2008-08-16)
An infant animal isolated from its mother emits vocalizations spanning from the audible to the ultrasonic. These vocalizations are believed to represent distress signals from the pup. However, the neurobiological basis for vocalizations elicited by isolation has not been well
James L Goodson et al.
Hormones and behavior, 50(2), 223-236 (2006-04-29)
Neuroendocrine factors that produce species differences in aggregation behavior ("sociality") are largely unknown, although relevant studies should yield important insights into mechanisms of affiliation and social evolution. We here focused on five species in the avian family Estrildidae that differ
David A Lovejoy et al.
General and comparative endocrinology, 146(1), 1-8 (2006-02-14)
The corticotropin-releasing factor (CRF) family of peptides consists of four distinct paralogs found on separate chromosomes in vertebrates. Among invertebrates, the family has been relatively well characterized in the insects where at least 2 or 3 paralogs, a CRF-binding protein
Donald R Gehlert et al.
The Journal of pharmacology and experimental therapeutics, 341(3), 672-680 (2012-03-10)
Corticotropin-releasing factor (CRF) is the major hypothalamic neuropeptide responsible for stimulation of the hypothalamic-pituitary-adrenal axis (HPAA), resulting in the synthesis and release of glucocorticoids from the adrenal cortex. In a recent study, we reported the discovery of the CRF1 receptor
Handbook of Biologically Active Peptides (2013)
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