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Merck

S3821

Sigma-Aldrich

Anti-phospho-Synaptotagmin (Ser309) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.44

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

usage

sufficient for 10 blots

species reactivity

mouse, human, rat

technique(s)

dot blot: suitable
western blot: 1:1,000 using rat brain lysate

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SYT1(6857)
mouse ... Syt1(20979)
rat ... Syt1(25716)

General description

SYT1 (synaptotagmin-1) or phospho-Synaptotagmin is a calcium binding synaptic vesicle protein, that is located on chromosome 12q21. It is usually present in nerve cells.

Immunogen

synthetic phosphopeptide corresponding to amino acids residues surrounding the serine 309 of synaptotagmin (Syt).

Biochem/physiol Actions

Synaptotagmin-1 (SYT1) is an essential factor for exocytosis, endocytosis and vesicular Ca2+/H+ antiport activity.

Physical form

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl with 100 μg/mL BSA and 50% glycerol.

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related product

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld CD, et al.
Nature Communications, 8 (2017)
Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling
Baker K, et al.
The Journal of Clinical Investigation, 125(4), 1670-1678 (2015)
Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail
Vermaas JV and Tajkhorshid E
Biochemistry, 56(1), 281-293 (2017)
Salvatore Santamaria et al.
mAbs, 9(4), 595-602 (2017-03-18)
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Anna-Carina Weiss et al.
Development (Cambridge, England), 141(17), 3420-3430 (2014-08-21)
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