R5145

Anti-Rsk1 antibody produced in rabbit

whole antiserum

• Sinónimos: Anti-p90^rsk
• MDL number: MFCD00676462
• UNSPSC Code: 12352203
• NACRES: NA.44

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: whole antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• mol wt: antigen 80 kDa
• contains: 15 mM sodium azide
• species reactivity: mouse, rat, human
• technique(s): microarray: suitable; western blot: 1:4,000 using mouse NIH 3T3 fibroblast cell lysate and rat brain extract
• UniProt accession no.: Q15418
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... RPS6KA1(6195) ; mouse ... Rps6ka1(20111) ; rat ... Rps6ka1(81771)

Descripción

General description

Ribosomal S6 kinase 1(Rsk1) is a ubiquitously expressed, mitogen-activated protein that belongs to the serine/threonine protein kinases family. Several isoforms of Rsk have been cloned from mouse (Mo1 and Mo2) 4, 5 and human (HU1-3) source. All of these isoforms encode proteins with calculated molecular masses of about 70 kDa. Their apparent higher masses (90 kDa) may be due to hyperphosphorylation after activation.

Immunogen

Synthetic peptide corresponding to amino acids 707-723 of human Rsk1 coupled to KLH.

Application

Anti-Rsk1 antibody can be used in microarray and western blotting.

Biochem/physiol Actions

Ribosomal S6 kinase 1(Rsk1) is regulated via separate signal transduction pathways in response to mitogenic stimulation. It is an important component in nuclear signaling processes. Activation of p90rsk occurs rapidly through phosphorylation of Thr396 located in the kinase catalytic domain. Rsk can phosphorylate and regulate the activity of other molecules such as transcription factor c-fos.

Rsk1 has a pivotal role in facilitating MEK-MAP kinase cell survival signaling and supressing pro-apoptotic function of BAD by phosphorylating . Anti-Rsk1 antibody can be used for studying differential tissue expression of (p90rsk) and its intracellular localization in normal and neoplastic tissues. It can also be used to detect (p90rsk).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.