PZ0261

PF-06649283

≥98% (HPLC)

• Sinónimos: (4R,4aR,6R,8aS)-8a-(2,4-Difluoro-phenyl)-4-methyl-6-(3-methyl-isoxazol-5-yl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-aza-naphthalen-2-ylamine, (4R,4aR,6R,8aS)-8a-(2,4-Difluorophenyl)-4,4a,5,6,8,8a-hexahydro-4-methyl-6-(3-methyl-5-isoxazolyl)-pyrano[3,4-d][1,3]thiazin-2-amine, PF06649283
• Fórmula empírica (notación de Hill): C₁₈H₁₉F₂N₃O₂S
• Número de CAS: 1621585-17-8
• Peso molecular: 379.42
• MDL number: MFCD28580118
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823797
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C[C@@H]1[C@@]2([H])[C@@](CO[C@@H](C3=CC(C)=NO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S1
• InChI: 1S/C18H19F2N3O2S/c1-9-5-16(25-23-9)15-7-13-10(2)26-17(21)22-18(13,8-24-15)12-4-3-11(19)6-14(12)20/h3-6,10,13,15H,7-8H2,1-2H3,(H2,21,22)/t10-,13+,15-,18-/m1/s1
• InChI key: HVEVDFRWOQHAPJ-CKMNQQOVSA-N

Descripción

Biochem/physiol Actions

PF-06649283 is a new β-Secretase (BACE) inhibitor.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable