P9248

PD 169316

≥98% (HPLC), solid

• Sinónimos: 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
• Fórmula empírica (notación de Hill): C₂₀H₁₃FN₄O₂
• Número de CAS: 152121-53-4
• Peso molecular: 360.34
• MDL number: MFCD12405019
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278156
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: faint yellow to dark orange
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
• InChI key: BGIYKDUASORTBB-UHFFFAOYSA-N
• Gene Information: human ... MAPK14(1432)

Descripción

General description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases.[1] It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.[2]

application

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes.[3] It has been used in culture media to promote embryoid bodies differentiation.[4]

Biochem/physiol Actions

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS06,GHS05
• signalword: Danger
• hcodes: H301,H315,H318,H335
• pcodes: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves