P4668
Praziquantel
anthelminic, neurogenic
Sinónimos:
2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
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About This Item
Fórmula empírica (notación de Hill):
C19H24N2O2
Número de CAS:
Peso molecular:
312.41
Beilstein:
761557
Número CE:
Número MDL:
Código UNSPSC:
51452701
ID de la sustancia en PubChem:
NACRES:
NA.85
Productos recomendados
Formulario
powder or crystals
espectro de actividad antibiótica
parasites
Modo de acción
cell membrane | interferes
temp. de almacenamiento
−20°C
cadena SMILES
O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
InChI
1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
Clave InChI
FSVJFNAIGNNGKK-UHFFFAOYSA-N
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Aplicación
Praziquantel is a potent anthelmintic used against schistosome and many cestode infestations. It is used to study voltage-gated Ca2+ channels and is a potential small molecule neurogenic[1].
Acciones bioquímicas o fisiológicas
Praziquantel increases the permeability of the tegmentum to Ca2+ which results in the contraction of schistosomes and death. Praziquantel causes vacuolization and disintegration of the schistosome tegument. It is more effective on adult worms than young worms. It inhibits glucose uptake, which lowers glycogen levels and stimulates lactate release. Praziquantel is a potent anthelmintic against parasitic flatworms (flukes and tapeworms). Recent studies have indicated that praziquantel binds to a varient of the β-subunit of the voltage gated Ca2+ channel and to actin, which is a component of some Ca2+ channels.
Otras notas
1g,5g,25g
Keep container tightly closed in a dry and well-ventilated place.
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Aquatic Chronic 3
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Los clientes también vieron
Yuxiang Dong et al.
Bioorganic & medicinal chemistry letters, 20(8), 2481-2484 (2010-03-23)
Six amide and four urea derivatives of praziquantel were synthesized and tested for antischistosomal activity against juvenile and adults stages of Schistosoma mansoni in infected mice. Only one of these had significant activity against adult worms, but, unlike praziquantel, six
R J Martin et al.
Parasitology, 114 Suppl, S111-S124 (1997-01-01)
This paper reviews sites of action of anthelmintic drugs including: (1) levamisole and pyrantel, which act as agonists at nicotinic acetylcholine receptors of nematodes; (2) the avermectins, which potentiate or gate the opening of glutamategated chloride channels found only in
Dan Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(44), 15983-15995 (2011-11-04)
There is intense interest in developing methods to regulate proliferation and differentiation of stem cells into neuronal fates for the purposes of regenerative medicine. One way to do this is through in vivo pharmacological engineering using small molecules. However, a
Fiona Ronketti et al.
Bioorganic & medicinal chemistry letters, 17(15), 4154-4157 (2007-06-09)
Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These
Jennifer A Downs et al.
Tropical medicine & international health : TM & IH, 18(9), 1090-1096 (2013-08-14)
We explored response to single-dose praziquantel therapy in a cohort of 33 women with Schistosoma haematobium infection in rural Mwanza, Tanzania. Women with S. haematobium infection confirmed both by eggs in urine and by polymerase chain reaction (PCR) received single-dose praziquantel
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