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P4505

Sigma-Aldrich

Protamine sulfate

powder

Sinónimos:

Clupeine

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1 G
MXP 1,163.00
5 G
MXP 2,964.00
25 G
MXP 11,625.00

MXP 1,163.00


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Seleccione un Tamaño

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1 G
MXP 1,163.00
5 G
MXP 2,964.00
25 G
MXP 11,625.00

About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

MXP 1,163.00


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Nombre del producto

Protamine sulfate salt from herring, Grade III, histone, free(Millon test)

origen biológico

fish (herring)

Nivel de calidad

tpo

Grade III

Formulario

powder

impurezas

histone, free (Millon test)

solubilidad

6 M HCl: 25 mg/mL, clear, colorless to very faintly yellow

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Aplicación

May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Acciones bioquímicas o fisiológicas

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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Los clientes también vieron

L Willmitzer et al.
Biophysics of structure and mechanism, 6(2), 95-110 (1980-01-01)
The thermodynamics of protamine-DNA interation was investigated with clupeine Z from herring labeled at its amino terminus with fluorescein. The ionic strength dependence, the influence of protamine phosphorylation, of the native DNA conformation, using native and heat-denatured DNA, and of
Lisanne T Laagland et al.
JOR spine, 5(3), e1219-e1219 (2022-10-08)
Repopulating the degenerated intervertebral disc (IVD) with tissue-specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell-based therapy has been hampered by the low cell numbers that can
L T Hansen et al.
International journal of food microbiology, 66(3), 149-161 (2001-06-29)
The antimicrobial effect of protamine (clupeine) on a range of gram-positive and gram-negative foodborne pathogens and spoilage bacteria, was evaluated using an agar dilution assay and a broth dilution assay with Alamar Blue as growth indicator. Protamine was tested alone
Chengming Liu et al.
BMC medicine, 20(1), 187-187 (2022-05-14)
Cytokines have been reported to alter the response to immune checkpoint inhibitors (ICIs) in patients with the tumor in accordance with their plasma concentrations. Here, we aimed to identify the key cytokines which influenced the responses and stimulated resistance to
C Toniolo et al.
Biochimica et biophysica acta, 576(2), 429-439 (1979-02-26)
The three main components YI, YII, and Z of clupeine, a protamine from herring, have been purified and characterized. The conformational preferences of clupeines have been examined as a funciton of pH, temperature, added salts, and presence of structure-disrupting agents

Questions

  1. Is it possible to confirm whether product P4505 contains salts (Mg+2, Na+) as impurities or due to its origin?

    1 answer
    1. There is no information regarding the presence of other salts, as the product is currently sourced from an external supplier(s). The supplier's Certificate of Analysis does not mention the testing for salts such as magnesium or calcium.

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