Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

P3371

Sigma-Aldrich

Penfluridol

≥97% (HPLC), powder

Sinónimos:

1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Seleccione un Tamaño

50 MG
MXP 4,566.00

MXP 4,566.00

Check Cart for Availability
Solicitar un pedido a granel
Todas las fotos(1)

Seleccione un Tamaño

Cambiar Vistas
50 MG
MXP 4,566.00

About This Item

Fórmula empírica (notación de Hill):
C28H27ClF5NO
Número de CAS:
26864-56-2
Peso molecular:
523.97
Número CE:
248-074-5
Número MDL:
MFCD00866714
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329820171
NACRES:
NA.77

MXP 4,566.00

Check Cart for Availability
Solicitar un pedido a granel

Ensayo

≥97% (HPLC)

Formulario

powder

color

white

solubilidad

DMSO: >20 mg/mL
H2O: insoluble

emisor

Johnson & Johnson

temp. de almacenamiento

2-8°C

cadena SMILES

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

Clave InChI

MDLAAYDRRZXJIF-UHFFFAOYSA-N

Aplicación

Penfluridol has been used as an antipsychotic agent:
  • to study its antimetastatic effect on triple-negative breast cancer cells[1]
  • to study its effects on the growth of glioblastoma cell lines[1],
  • to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)[2]

Acciones bioquímicas o fisiológicas

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis.[2] It also exhibits anticancer activity.[1]
T-type Ca2+ channel blocker; antipsychotic

Características y beneficios

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301

Clasificaciones de peligro

Acute Tox. 3 Oral

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
0000398879
0000398879
0000390430
0000390430
0000166335

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

J J Enyeart et al.
Molecular endocrinology (Baltimore, Md.), 7(8), 1031-1040 (1993-08-01)
The function of low voltage-activated T-type Ca2+ channels in ACTH-stimulated cortisol production by bovine adrenal zona fasciculata cells (AZF) was explored in patch clamp and secretion studies. Nearly all AZF cells expressed only a low voltage-activated T-type Ca2+ current (IT)
J G Won et al.
Endocrinology, 126(2), 858-868 (1990-02-01)
We examined the effects of removing extracellular Ca2+ (Ca2+e), depleting intracellular Ca2+ (Ca2+i), inhibiting cAMP-dependent calmodulin, and blocking voltage-sensitive Ca2+ channels on the secretion of ACTH by perifused dispersed rat anterior pituitary cells. The cells were stimulated with synthetic arginine
Orna Diav-Citrin et al.
The Journal of clinical psychiatry, 66(3), 317-322 (2005-03-16)
To assess the safety of the butyrophenone neuroleptics haloperidol and penfluridol in pregnancy. The rate of major anomalies was compared between a cohort of pregnant women counseled for gestational exposure to haloperidol or penfluridol and a control group counseled for
J C Gomora et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 266-275 (1999-06-25)
Bovine adrenal zona fasciculata cells express a novel K+ current (IAC) that sets the resting potential while it couples adrenocorticotropin and angiotensin II receptors to membrane depolarization and cortisol secretion. IAC is distinctive among K+ channels both in its activation
J J Enyeart et al.
The Journal of biological chemistry, 265(27), 16373-16379 (1990-09-25)
The effects of diphenylbutylpiperidine (DPBP) antipsychotics on Ca2+ currents and prolactin (PRL) synthesis were studied in rat pituitary growth hormone (GH) cell lines (GH3 and GH4C1). In whole-cell patch-clamp experiments, DPBPs including fluspirilene, penfluridol, and pimozide at concentrations ranging from
Ver todos los artículos relacionados

Questions

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico