P0026

Pilsicainide hydrochloride

≥98% (HPLC)

• Sinónimos: N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide hydrochloride, Pilzicainide hydrochloride, SUN 1165
• Fórmula empírica (notación de Hill): C₁₇H₂₄N₂O · xHCl
• Número de CAS: 88069-49-2
• Peso molecular: 272.39 (free base basis)
• Número MDL: MFCD00903769
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329819981
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: deionized water: >5 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: Cl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3
• InChI: 1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
• Clave InChI: NZOSVDHCTCLGEB-UHFFFAOYSA-N

Descripción

Aplicación

Pilsicainide hydrochloride has been used as a sodium channel blocker:

• to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation[1]
• to study its effects on Ca²⁺ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes[2]
• to study its electrophysiological effects on the guinea pig atrium[3]

Acciones bioquímicas o fisiológicas

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels.

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na⁺¹ channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(⁺) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable