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O5501

Sigma-Aldrich

Oxyphenonium bromide

Sinónimos:

2-([Cyclohexylhydroxyphenylacetyl]oxy)-N,N-diethyl-N-methylethanaminium bromide

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About This Item

Fórmula lineal:
C21H34NO3Br
Número de CAS:
50-10-2
Peso molecular:
428.40
EC Number:
200-010-7
MDL number:
MFCD00050259
UNSPSC Code:
12161900
PubChem Substance ID:
24898019

description

cationic

assay

>98% (TLC)

mol wt

428.40 g/mol

SMILES string

Br.CC[N](C)(CC)CCOC(=O)C(O)(C1CCCCC1)c2ccccc2

InChI

1S/C21H34NO3.BrH/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3;1H

InChI key

JKJFWDDPBNHJPV-UHFFFAOYSA-N

Application

Oxyphenonium bromide has been used in a study to assess masking mechanisms of bitter taste of drugs. It has also been used in a study to investigate stoichiometric and microenvironmental effects on hydrolysis of propantheline in cyclodextrin solutions.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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G I Nezhinskaya et al.
Bulletin of experimental biology and medicine, 145(1), 55-57 (2008-11-26)
Blood plasma proteins modulated the effects of muscarinic receptor antagonist methacin. Administration of methacin in combination with albumin or C-reactive protein (but not with IgG) abolished the broncholytic effect of methacin. It was probably associated with allosteric antagonism to M2
V A Kozhevnikov et al.
Anesteziologiia i reanimatologiia, (5)(5), 15-19 (2006-12-23)
The good tolerability of sevoflurane, the mild and prompt onset of a hypnotic state, the absence of airway irritation, and the safe use of the agent make the anesthetic of choice for introductory anesthesia in pediatric cardiosurgery. The purpose of
T P Berezina et al.
Bulletin of experimental biology and medicine, 147(3), 296-300 (2009-06-17)
Psychogenic stress in rabbits (fixation to a frame) was accompanied by the inhibition of contractile activity of the gastric antrum and pylorus. These changes persisted during blockade of muscarinic receptors, nicotinic receptors, alpha(2)-adrenoceptors, and beta(1)/beta(2) adrenoceptors. A stress-induced decrease in
N Funasaki et al.
Journal of pharmaceutical sciences, 90(6), 740-748 (2001-05-18)
The effects of alpha-, beta-, and gamma-cyclodextrins (CDs) on the basic hydrolysis of propantheline bromide (PB) and oxyphenonium bromide (OB) are analyzed in terms of the stoichiometry and microenvironments of their complexes. The rate constant of each species is evaluated
N Ya Kovalenko et al.
Bulletin of experimental biology and medicine, 140(2), 177-180 (2005-11-12)
Experiments employing ultrasound technique showed that nonselective blockade of central muscarinic cholinoceptors with amizyl significantly increases the number and lifespan of rats highly resistant to acute massive blood loss. This pretreatment increased individual resistance of the circulatory system to posthemorrhagic
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