Binds and blocks the acitivity of bone morphogenetic proteins (BMPs).
Binds and blocks the acitivity of bone morphogenetic proteins (BMPs). Mature mouse noggin shares 99% and 83% sequence identity with human and Xenopus noggin, respectively.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Nota de análisis
The biological activity is measured by its ability to inhibit recombinant human BMP-4 induced alkaline phosphatase activity in ATDC5 cells.
This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis. BMPs are a family of growth and differentiation factors, and they act on mesenchymal cells to induce
Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding.
Marcelino J
Proceedings of the National Academy of Sciences of the USA (2001)
Large numbers of new neurons are born continuously in the adult subventricular zone (SVZ). The molecular niche of SVZ stem cells is poorly understood. Here, we show that the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells
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