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N4786

NPS 2390

Name: NPS 2390
Brand: SIGMA

≥99% (HPLC), solid

Sinónimos:

Quinoxaline-2-carboxylic acid adamantan-1-ylamide

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About This Item

Fórmula empírica (notación de Hill):

C₁₉H₂₁ON₃

Número de CAS:

226878-01-9

Peso molecular:

307.39

MDL number:

MFCD05865239

UNSPSC Code:

12352200

PubChem Substance ID:

329818648

description

Caution-Not Yet Fully Tested-For Research Use Only-Not For Human Use.

assay

≥99% (HPLC)

form

solid

color

white

solubility

DMSO: soluble ~5 mg/mL
H₂O: insoluble

storage temp.

2-8°C

SMILES string

O=C(NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2)c4cnc5ccccc5n4

InChI

1S/C19H21N3O/c23-18(17-11-20-15-3-1-2-4-16(15)21-17)22-19-8-12-5-13(9-19)7-14(6-12)10-19/h1-4,11-14H,5-10H2,(H,22,23)/t12-,13+,14-,19-

InChI key

ZKFVOZCCAXQXBU-KRFSREQESA-N

Biochem/physiol Actions

Type I metabotropic glutamate receptor antagonist

Legal Information

Sold with the permission of NPS Pharmaceuticals, Inc. striclty for in vitro use only.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Structure-activity relationship studies of NPS 2390: A potent and selective group I metabotropic glutamate receptor antagonist.

Van Wagenen, B.C., et al.

Abstr. Soc. Neurosci, #618.3 (2000)

Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells.

Nicola Antonio Martino et al.

PloS one, 6(3), e17714-e17714 (2011-03-26)

The present study investigates the effects of high external calcium concentration ([Ca(2+)](o)) and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines. The involvement of

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.

Charalambos Kaittanis et al.

The Journal of experimental medicine, 215(1), 159-175 (2017-11-17)

Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in

Calcium-sensing receptor-mediated osteogenic and early-stage neurogenic differentiation in umbilical cord matrix mesenchymal stem cells from a large animal model.

Nicola Antonio Martino et al.

PloS one, 9(11), e111533-e111533 (2014-11-08)

Umbilical cord matrix mesenchymal stem cells (UCM-MSCs) present a wide range of potential therapeutical applications. The extracellular calcium-sensing receptor (CaSR) regulates physiological and pathological processes. We investigated, in a large animal model, the involvement of CaSR in triggering osteogenic and

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