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N1517

Sigma-Aldrich

N-Nitroso-N-methylurea

ISOPAC®

Sinónimos:

MNU, N-Methyl-N-nitrosourea

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About This Item

Fórmula empírica (notación de Hill):
C2H5N3O2
Número de CAS:
684-93-5
Peso molecular:
103.08
Número MDL:
MFCD00014794
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24897498

temp. de almacenamiento

2-8°C

cadena SMILES

CN(N=O)C(N)=O

InChI

1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

Clave InChI

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

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Acciones bioquímicas o fisiológicas

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Envase

Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.

Precaución

Injecting any compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.

Reconstitución

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Información legal

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC de

Referencia del producto
Descripción
Precios

N4766

N-Nitroso-N-methylurea, Bulk package

Palabra de señalización

Danger

Frases de peligro

H228,H301,H350,H360

Clasificaciones de peligro

Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B

Código de clase de almacenamiento

4.1B - Flammable solid hazardous materials

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
MKBQ7120V
SLBH1819V
SLBF6813V
SLBC9358V
SLBC2876V

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Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the purity of N-Nitroso-N-methylurea - ISOPAC®, Product N1517?

    Product No. N1517 is not assayed for purity.

  4. Is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, hazardous material?

    Yes, N-Nitroso-N-methylurea (MNU) is extremely hazardous. It is a known carcinogen. N1517 is packaged as an ISOPAC so that the material does not need to weighed out. Any precautions that one can take to minimize handling the material would be advisable.

  5. What is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, soluble in?

    Dissolving the contents in 100 mL of solvent yields a 1% solution. We would recommend using either ethanol or DMSO as the solvent. MNU has very poor stability in aqueous solutions.

  6. The package size of N-Nitroso-N-methylurea - ISOPAC®, Product N1517, is 1 gram (N1517-1G), but I see that this product also contains acetic acid and water. How much of each is in the bottle?

    Each bottle contains 1 gram of MNU. There is a significant amount of acetic acid and water present; the specific quantities are given on the certificate of analysis of each lot. Including the acetic acid and water, the total amount of material in each bottle will typically be in the 1-2 gram range.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Yuan-Yuan Chen et al.
Experimental eye research, 121, 102-113 (2014-02-11)
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Alice A Ramos et al.
Journal of toxicology and environmental health. Part A, 75(13-15), 765-775 (2012-07-14)
DNA damage induced by oxidative and alkylating agents contributes to carcinogenesis, leading to possible mutations if replication proceeds without proper repair. However, some alkylating agents are used in cancer therapy due to their ability to induce DNA damage and subsequently
Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
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