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Merck
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MAK222

Sigma-Aldrich

Beta-Lactamase Inhibitor Screening Kit

Sufficient for 100 Colorimetric tests

Sinónimos:

β-Lactamase Inhibitor Screening Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

detection method

colorimetric

storage temp.

−20°C

Categorías relacionadas

General description

β-Lactamase (β-lactamase, βL, EC 3.5.2.6) is an enzyme first identified in Escherichia coli and has been described as penicillinase. A number of βLs have since been identified from various bacteria. β-Lactamases specifically hydrolyze β-lactam rings present in antibiotics such as penicillin, cephalosporins, monobactam, and carbapenem, and confer resistance against these antibiotics.

Application

Beta-Lactamase Inhibitor Screening Kit has been used in enzymatic assays.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the screening of inhibitors of β-Lactamase

Principle

The β-Lactamase Inhibitor Screening Kit is a rapid, simple and sensitive assay that is suitable for high throughput screening of β-Lactamase inhibitors. βL activity is measured by hydrolyzing a chromogenic cephalosporin called nitrocefin, producing a colorimetric product (A490), proportional to the enzymatic activity present.

Solo componentes del kit

Referencia del producto
Descripción
  • β-Lactamase Assay Buffer
  • Nitrocefin, in DMSO
  • β-Lactamase
  • Inhibitor Control, Clavulanic acid

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

10 - Combustible liquids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Evaluation of 1, 4, 7-Triazacyclononane (TACN) as a potential Metallo-B-Lactamase inhibitor in Enterobacteriaceae: Restoring the Activity of B-lactams
Somboro A M, et al.
bioRxiv, 366146-366146 (2018)
Anou M Somboro et al.
Applied and environmental microbiology, 85(3) (2018-11-28)
Metallo-β-lactamase (MBL)-producing Enterobacteriaceae are of grave clinical concern, particularly as there are no metallo-β-lactamase inhibitors approved for clinical use. The discovery and development of MBL inhibitors to restore the efficacy of available β-lactams are thus imperative. We investigated a zinc-chelating

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