M9808
Anti-Muscarinic Acetylcholine Receptor (M1) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinónimos:
Acetylcholine Receptor antibody
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0.2 ML
MXP 19,788.00
MXP 19,788.00
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0.2 ML
MXP 19,788.00
About This Item
MXP 19,788.00
Check Cart for Availability
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
mouse, rat
técnicas
immunoblotting: 1:200 using rat brain membranes
immunohistochemistry: suitable
Nº de acceso UniProt
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CHRM1(1128)
rat ... Chrm1(25229)
Descripción general
Muscarinic acetylcholine receptor 1 (M1) is a member of class A G protein-coupled receptors (GPCRs) family, which is encoded by the CHRM1 gene. Muscarinic receptors have seven transmembrane domains localized in the parasympathetic nerve sub-synaptic membrane. The CHRM1 gene is located on human chromosome location 11q12.3.
Muscarinic cholinergic receptor 1 (M1) is seen in the forebrain of rats.
Inmunógeno
GST fusion protein of a part of the i3 intracellular loop of human M1 muscarinic acetylcholine receptor (mAChR) corresponding to amino acid residues 227-353.1, 2
Aplicación
Anti-Muscarinic acetylcholine receptor (M1) antibody produced in rabbit has been used in immunohistochemistry and Western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Acciones bioquímicas o fisiológicas
Muscarinic acetylcholine receptor 1 (M1) regulates normal prostate growth and reduced-level glandular secretion. Muscarinic receptors play a major role in tumor progression. Muscarinic acetylcholine receptors (mAChRs) regulates adenylyl cyclase and potassium channel activities. It also stimulates various mitogen-activated protein kinases. M1 may be useful for the discovery of therapeutics for Alzheimer′s disease.
Studies have shown that activation of muscarinic cholinergic receptor 1 (M1) in rats leads to changes in the endotoxin tolerance in the liver.
Forma física
Lyophilized from a solution of phosphate-buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Aurelia Lugea et al.
Alcoholism, clinical and experimental research, 34(10), 1768-1781 (2010-07-16)
The mechanisms initiating pancreatitis in patients with chronic alcohol abuse are poorly understood. Although alcohol feeding has been previously suggested to alter cholinergic pathways, the effects of these cholinergic alterations in promoting pancreatitis have not been characterized. For this study
Sophie R Thomson et al.
Neuron, 95(3), 550-563 (2017-08-05)
Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu
Golnar Eftekhari et al.
European journal of pharmacology, 740, 436-441 (2014-07-11)
Endotoxin tolerance is a mechanism in which cells receiving low doses of endotoxin, enter a transient phase with less inflammatory response to the next endotoxin challenges. Central nervous system is known to modulate systemic inflammation through activation of the cholinergic
Tamara Stojanovic et al.
Cells, 11(2) (2022-01-22)
Nicotine addiction develops predominantly during human adolescence through smoking. Self-administration experiments in rodents verify this biological preponderance to adolescence, suggesting evolutionary-conserved and age-defined mechanisms which influence the susceptibility to nicotine addiction. The hippocampus, a brain region linked to drug-related memory
Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling
Yin QQ, et al.
Asian Journal of Andrology, 20(6), 608-608 (2018)
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