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M9149

Sigma-Aldrich

Mepartricin

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About This Item

Número de CAS:
11121-32-7
MDL number:
MFCD00070325
UNSPSC Code:
51101500
PubChem Substance ID:
329818084

potency

3700 units Mepartricin per mg

color

yellow to yellow with tan cast powder

solubility

DMF: 50 mg/mL, slightly hazy, red to red-brown

antibiotic activity spectrum

fungi

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

COC(=O)C1C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)OC(C(C)CCC(O)CC(=O)c3ccc(N)cc3)C(C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(CC1O2)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O

InChI

1S/C59H86N2O19/c1-35-17-15-13-11-9-7-5-6-8-10-12-14-16-18-47(78-58-55(73)53(61)54(72)37(3)77-58)32-50-52(57(74)76-4)49(70)34-59(75,80-50)33-46(68)29-44(66)27-42(64)25-41(63)26-43(65)28-45(67)31-51(71)79-56(35)36(2)19-24-40(62)30-48(69)38-20-22-39(60)23-21-38/h5-18,20-23,35-37,40-42,44-47,49-50,52-56,58,62-64,66-68,70,72-73,75H,19,24-34,60-61H2,1-4H3/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t35?,36?,37-,40?,41?,42?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58+,59?/m1/s1

InChI key

GIDIUOCSTCGLRW-QJSPMWJNSA-N

General description

Chemical structure: macrolide

Application

Mepartricin is a polyene antibacterial with antifungal and antiprotozoal activity. It is an Amphotericin B(AmB) analogue and has been used to study scrapie. It is used as an antibiotic supplement in cell culture.
Mepartricin is used in studies on sterol biosynthesis and bacterial cell membranes. It may be incorporated into liposomes

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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F C Lowe et al.
The Prostate, 37(3), 187-193 (1998-10-29)
In order to assess the efficacy of phytotherapeutic agents for the treatment of benign prostatic hyperplasia (BPH), a review of recently published double-blind placebo-controlled trials was undertaken. Only those studies reviewed by the Other Medical Therapies Committee of the Fourth
D Prezioso et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 48(4), 207-211 (1996-12-01)
The therapeutic efficacy and tolerance of a new 150,000 U (40 mg) formulation of mepartricin (to be administered once-a-day in the evening) were evaluated during a double-blind study against placebo in 2 groups of uncomplicated BPH patients treated for 60
S Parziani et al.
European urology, 26(2), 115-119 (1994-01-01)
The urethral syndrome is very frequent in women but the etiology is unknown. In all 77 patients suffering from the syndrome, endoscopy revealed characteristic lesions in the trigonal area. As unidentified bacteria may be responsible, a microbiological investigation was carried
Maria Manuel Quintela
Historia, ciencias, saude--Manguinhos, 11 Suppl 1, 239-260 (2004-09-29)
Based on nineteenth - and twentieth-century texts, the article discusses how medicine legitimized the therapeutic practice of thermalism as so-called 'scientific' knowledge, with the creation of therapeutic establishments and hot-springs resort. My research began in Portugal in 1996, where I
S Shakutou et al.
The Prostate, 38(1), 17-27 (1999-02-11)
Mepartricin, an antifungal agent, was investigated for effects on fecal excretion and serum concentration of sex steroids and the number of sex steroid prostatic receptors in immature rats. Mepartricin was orally administered at 2.5, 5, and 10 mg/kg once daily
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