M9066
Microsomes from Liver, Pooled
from rat(Sprague-Dawley), male
Sinónimos:
Liver microsome preparation
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About This Item
UNSPSC Code:
12161501
NACRES:
NA.47
El producto M9066 no se vende actualmente en su país Póngase en contacto con el Servicio técnico
Productos recomendados
biological source
rat (Sprague-Dawley)
Quality Level
form
liquid
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
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General description
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).[1]
Application
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis.[1] Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids.[4] Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.[3]
Source of drug metabolizing enzymes, including cytochrome P-450.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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