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M6403

(±)-3,4-Methylenedioxymethamphetamine hydrochloride

Name: (±)-3,4-Methylenedioxymethamphetamine hydrochloride
Brand: SIGMA

Sinónimos:

(±)-MDMA hydrochloride, DL-3,4-Methylenedioxymethamphetamine, DL-MDMA hydrochloride, Ecstasy, XTC hydrochloride

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About This Item

Fórmula empírica (notación de Hill):

C₁₁H₁₅NO₂ · HCl

Número de CAS:

64057-70-1

Peso molecular:

229.70

MDL number:

MFCD00079444

UNSPSC Code:

12352116

PubChem Substance ID:

24897006

NACRES:

NA.77

El producto M6403 no se vende actualmente en su país Póngase en contacto con el Servicio técnico

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Greiner CELLSTAR^® 384 well plates

Sigma-Aldrich

S1875

(−)-Scopolamine hydrobromide trihydrate

Supelco

P-173

1P-LSD solution

Quality Level

200

drug control

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H₂O: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

SMILES string

Cl[H].CNC(C)Cc1ccc2OCOc2c1

InChI

1S/C11H15NO2.ClH/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10;/h3-4,6,8,12H,5,7H2,1-2H3;1H

InChI key

LUWHVONVCYWRMZ-UHFFFAOYSA-N

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Biochem/physiol Actions

Hallucinogen; releases serotonin and dopamine from axon terminals; selective serotonergic neurotoxin.

pictograms

GHS06

signalword

Danger

hcodes

H301,H336

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number

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Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum.

Zahra Nazari et al.

Iranian journal of basic medical sciences, 25(9), 1091-1096 (2022-10-18)

Ecstasy is a popular recreational psychostimulant with side effects on the central nervous system. This study examined the corpus striatum tissue of adult rats that received ecstasy during the embryonic period for histological and molecular studies. Rats were divided into

(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals.

G A Ricaurte et al.

Neuropsychobiology, 42(1), 5-10 (2000-06-27)

The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons. Although

Investigation of the prejunctional alpha2-adrenoceptor mediated actions of MDMA in rat atrium and vas deferens.

A Lavelle et al.

British journal of pharmacology, 128(5), 975-980 (1999-11-11)

1. We have investigated the effects of methylenedioxymethamphetamine (MDMA, 'ecstasy') on peripheral noradrenergic neurotransmission in the rat. 2. In rat atrial slices pre-incubated with [3H]-noradrenaline and in the presence of desipramine (1 micronM) to prevent effects of MDMA on basal

Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphé nucleus slices.

M M Iravani et al.

Synapse (New York, N.Y.), 36(4), 275-285 (2000-05-20)

We examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine (MDMA) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-HT) or dopamine (DA) release in the caudate putamen (CPu), nucleus accumbens (NAc), substantia nigra pars reticulata

Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration.

M I Colado et al.

British journal of pharmacology, 126(4), 911-924 (1999-04-08)

1. We investigated whether dopamine plays a role in the neurodegeneration of 5-hydroxytryptamine (5-HT) nerve endings occurring in Dark Agouti rat brain after 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration. 2. Haloperidol (2 mg kg(-1) i.p.) injected 5 min prior and 55

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