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Merck

K1769

Sigma-Aldrich

Anti-KTN1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-CG-1 antigen, Anti-Kinectin 1 (kinesin receptor)

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

antigen ~150 kDa

reactividad de especies

human

envase

antibody small pack of 25 μL

concentración

~1.0 mg/mL

técnicas

immunoprecipitation (IP): 2-5 μg using lysate of Raji cells
indirect immunofluorescence: 2-5 μg/mL using human HeLa cells
western blot: 1-2 μg/mL using whole extract of human HeLa cells

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... KTN1(3895)

Descripción general

Kinectin (KTN1) protein is mainly located in the endoplasmic (ER) reticulum and is a large integral protein. This protein is made up of an N-terminal transmembrane domain and a C-terminal kinesin-binding domain. The KTN1 gene is mapped on the human chromosome at 14q22.3.

Especificidad

Anti-KTN1 recognizes human KTN1.

Aplicación

Anti-KTN1 antibody produced in rabbit may be used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Acciones bioquímicas o fisiológicas

Kinectin (KTN1) protein coheres to kinesin and is involved in vesicle transport on microtubules. This protein is also related to fibronectin-integrin adhesion sites.

Forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Almacenamiento y estabilidad

Store at at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Huan Tran et al.
Journal of cell science, 115(Pt 10), 2031-2040 (2002-04-26)
Integrin receptors mediate the formation of adhesion complexes and play important roles in signal transduction from the extracellular matrix. Integrin-based adhesion complexes (IAC) contain proteins that link integrins to the cytoskeleton and recruit signaling molecules, including vinculin, paxillin, focal adhesion
Derrek P Hibar et al.
Nature, 520(7546), 224-229 (2015-01-22)
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To
Lee-Lee Ong et al.
The Journal of biological chemistry, 281(44), 33621-33634 (2006-09-05)
Kinectin is an integral membrane protein with many isoforms primarily found on the endoplasmic reticulum. It has been found to bind kinesin, Rho GTPase, and translation elongation factor-1delta. None of the existing models for the quaternary organization of the elongation

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