J2128
Anti-phospho-c-Jun (pSer63) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous glycerol solution
mol peso
antigen 48 kDa
reactividad de especies
rat, mouse, human
técnicas
flow cytometry: 1:200
microarray: suitable
western blot (chemiluminescent): 1:1,000 using extract of NIH3T3 anisomycin or UV-treated cells
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pSer63)
Información sobre el gen
human ... JUN(3725)
mouse ... Jun(16476)
Especificidad
The antibody does not react with the corresponding phosphorylated form of JunD or JunB.
Inmunógeno
synthetic phosphoserine63 peptide corresponding to residues around Ser63 of human c-Jun, conjugated to KLH.
Aplicación
Anti-phospho-c-Jun (pSer63) antibody produced in rabbit has been used in microarray analysis to identify the changes in the level of cellular proteins in cells inoculated with Equine influenza virus.[1]
Acciones bioquímicas o fisiológicas
The protooncogene c-Jun encodes a member of the jun family that forms a component of the transcription factor AP-1 (Activator Protein-1). It dimerizes with a member of the Fos family via the leucine-zipper motif to form AP-1, a factor involved in binding to TPA (12-O-tetradecanoylphorbol 13-acetate) response element (TRE) of various genes that include human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. The dimers formed are involved in the activation of AP-1 dependent genes. AP-1 regulates the transcription of mammalian DDI (DNA-damage-inducible) genes.
Forma física
Solution in 10 mM HEPES sodium, pH 7.5, containing 150 mM sodium chloride, 100 μg/mL bovine serum albumin, and 50% glycerol.
¿No encuentra el producto adecuado?
Pruebe nuestro Herramienta de selección de productos.
Código de clase de almacenamiento
10 - Combustible liquids
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
P Angel et al.
Cell, 55(5), 875-885 (1988-12-02)
Binding of the human transcription factor Jun/AP-1 to a conserved 8 bp nucleotide sequence (TRE) is responsible for increased transcription of different cellular genes in response to tumor promoters, such as TPA, and serum factors. Enhanced Jun/AP-1 activity in TPA-stimulated
Y Devary et al.
Molecular and cellular biology, 11(5), 2804-2811 (1991-05-01)
Exposure of mammalian cells to DNA-damaging agents leads to activation of a genetic response known as the UV response. Because several previously identified UV-inducible genes contain AP-1 binding sites within their promoters, we investigated the induction of AP-1 activity by
K Ryder et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(5), 1500-1503 (1989-03-01)
The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth factors. We report here the cloning and analysis of a cDNA encoding
D A Brenner et al.
Nature, 337(6208), 661-663 (1989-02-16)
Tumour necrosis factor-alpha (TNF-alpha) is secreted by macrophages in response to inflammation, infection and cancer. Sublethal doses of recombinant TNF-alpha to rats causes cachexia, anaemia and inflammation. TNF-alpha plays a major part in tissue inflammation and remodelling by stimulating production
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.
P Angel et al.
Biochimica et biophysica acta, 1072(2-3), 129-157 (1991-12-10)
Active Filters
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico
