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I5532

Sigma-Aldrich

Anti-Interleukin-21 Receptor, N-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-IL-21R

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About This Item

MDL number:
MFCD03455325
UNSPSC Code:
51111800

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~60 kDa

species reactivity

human

concentration

~0.5 mg/mL

technique(s)

western blot: 0.5-1 μg/mL

UniProt accession no.

Q9HBE5

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL21R(50615)

Immunogen

synthetic peptide corresponding to amino acids 20-32 of human IL-21 receptor precursor.

Biochem/physiol Actions

Interleukin-21 (IL-21) is a cytokine that regulates both innate and adaptive immunity. The biological effects of IL-21 are mediated by a heterodimeric receptor made up of IL-21R and a γ chain subunit. IL-21R is expressed in liver, thymus, dendritic cells , lymph nodes and spleen. Binding of IL-21 to the receptor leads to activation of JAK (JAK1 and JAK3), STAT (STAT1, 3, 4 and 5) proteins. IL-21R is important for sustained T cell responses during chronic viral infections, production of interferons against pathogens and protection against tumor formation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Giovanni Monteleone et al.
Discovery medicine, 8(42), 113-117 (2009-10-17)
Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin
John S Yi et al.
Microbes and infection, 12(14-15), 1111-1119 (2010-09-08)
Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical
Massimiliano Sarra et al.
Journal of biomedicine & biotechnology, 2010, 294582-294582 (2010-07-24)
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however evidence that B and

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