I4907
Anti-IKKε/IKK-i, C-Terminal antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-IKB Kinase
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About This Item
Número MDL:
Código UNSPSC:
12352203
origen biológico
rabbit
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen ~80 kDa
reactividad de especies
human
concentración
~1.0 mg/mL
técnicas
western blot: 0.5-1 μg/mL
Nº de acceso UniProt
aplicaciones
research pathology
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... IKBKE(9641)
Descripción general
IKK-epsilon/IKK-I belongs to IκB kinase complex and express mainly in immune cells. IKK-I express in response to proinflammatory cytokines such as tumor necrosis factor-α, IL-, IL-6 and stimulate NF-κB activation, hence referred as inducible IκB kinase . Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoblotting to detect human IKK epsilon/IKK-I. Anti-IKK epsilon/IKK-I antibodies can react specifically with human IKK epsilon/IKK-I and show no cross reactivity with IKK α, IKK β and IKK γ.
Especificidad
The antibody show no cross-reactivity to IKKα, IKKβ, or IKKγ.
Inmunógeno
Synthetic peptide corresponding to amino acids 701-716 of human IKK-epsilon/IKK-I conjugated to KLH.
Aplicación
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoprecipitation and western blot.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Suhu Liu et al.
Blood advances, 2(23), 3428-3442 (2018-12-07)
To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compared
T Shimada et al.
International immunology, 11(8), 1357-1362 (1999-07-28)
Using the suppression subtractive hybridization technique, we isolated a novel kinase, IKK-i, whose message is drastically induced by lipopolysaccharide (LPS) in the mouse macrophage cell line RAW264. 7. The predicted protein contains the kinase domain in its N-terminus, which shares
Israel Cañadas et al.
Nature medicine, 24(8), 1143-1150 (2018-07-25)
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that
Jian-Ping Guo et al.
The Journal of biological chemistry, 285(6), 3676-3684 (2009-11-27)
IKKepsilon has recently been identified as a breast cancer oncogene. Elevated levels of IKKepsilon are associated with cell survival and growth. Here, we show that IKKepsilon interacts with and phosphorylates estrogen receptor alpha (ERalpha) on serine 167 in vitro and
R T Peters et al.
Molecular cell, 5(3), 513-522 (2000-07-06)
Here we report the identification of a novel PMA-inducible IkappaB kinase complex, distinct from the well-characterized high-molecular weight IkappaB kinase complex containing IKKalpha, IKKbeta, and IKKgamma. We have characterized one kinase from this complex, which we designate IKKepsilon. Although recombinant
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