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Documentos clave

I4638

Sigma-Aldrich

Interleukin-1β Fragment 163-171 human

≥97% (HPLC), synthetic

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About This Item

Fórmula empírica (notación de Hill):
C39H64N12O19
Número de CAS:
Peso molecular:
1004.99
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:

biological source

synthetic

assay

≥97% (HPLC)

form

powder

mol wt

Mw 1004.99

packaging

pkg of 1 mg

color

white

solubility

water: soluble 1 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

SMILES string

CC(C)[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C39H64N12O19/c1-17(2)31(43)38(68)47-18(6-9-25(41)53)32(62)44-15-27(55)45-19(7-10-28(56)57)33(63)46-20(8-11-29(58)59)34(64)51-24(16-52)37(67)49-22(13-26(42)54)35(65)50-23(14-30(60)61)36(66)48-21(39(69)70)5-3-4-12-40/h17-24,31,52H,3-16,40,43H2,1-2H3,(H2,41,53)(H2,42,54)(H,44,62)(H,45,55)(H,46,63)(H,47,68)(H,48,66)(H,49,67)(H,50,65)(H,51,64)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t18-,19-,20-,21-,22-,23-,24-,31-/m0/s1

InChI key

NIXBZDOQHRZFDR-OEWCNXHOSA-N

Gene Information

human ... IL1B(3553)

Amino Acid Sequence

Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys

Biochem/physiol Actions

IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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G Antoni et al.
Journal of immunology (Baltimore, Md. : 1950), 137(10), 3201-3204 (1986-11-15)
Short peptide fragments of human and murine interleukin 1 (IL 1) were synthesized on the basis of their predicted exposure on the surface of the molecule in an attempt to identify the minimal structure responsible for the immunostimulatory activity of
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The Journal of surgical research, 172(1), e39-e46 (2011-11-15)
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Journal of immunology (Baltimore, Md. : 1950), 139(3), 800-804 (1987-08-01)
The stimulating effect of a synthetic nonapeptide (fragment 163-171) of human interleukin 1 beta (IL-1 beta) on antibody responses to both T helper-dependent and T helper-independent antigens was investigated. It was shown that the nonapeptide enhanced the antibody response, as
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Journal of biomedical materials research. Part A, 100(6), 1375-1386 (2012-03-13)
Poly(ethylene glycol) (PEG) hydrogels, modified with RGD, are promising platforms for cell encapsulation and tissue engineering. While these hydrogels offer tunable mechanical properties, the extent of the host response may limit their in vivo applicability. The overall objective was to

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