I4026
Interleukin-17 from mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinónimos:
CTLA-8, IL-17
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25 μG
MXP 10,859.00
MXP 10,859.00
Fecha estimada de envío29 de mayo de 2025
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25 μG
MXP 10,859.00
About This Item
MXP 10,859.00
Fecha estimada de envío29 de mayo de 2025
Productos recomendados
origen biológico
mouse
Nivel de calidad
recombinante
expressed in E. coli
Ensayo
≥97% (SDS-PAGE)
Formulario
lyophilized powder
mol peso
16.5 kDa
envase
pkg of 25 μg
técnicas
cell culture | mammalian: suitable
impurezas
endotoxin, tested
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Il17a(16171)
Acciones bioquímicas o fisiológicas
IL-17 (interleukin-17) participates in the activation of nuclear factor-κB and mitogen-activated protein kinase pathways and CCAAT/enhancer-binding protein family of transcription factors, thereby regulating pro-inflammatory and antimicrobial genes.[1] In rheumatoid arthritis, IL-17 is responsible for the inflammation as well as destruction of joints.[2]
Initially known as CTLA-8; is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system; has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
Forma física
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.
Nota de análisis
The biological activity of mouse IL-17 is measured by its ability to induce IL-6 production using NIH/3T3 cells.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Annica Andersson et al.
Clinical immunology (Orlando, Fla.), 161(2), 324-332 (2015-10-02)
Interleukin-17 (IL-17) drives inflammation and destruction of joints in rheumatoid arthritis (RA). The female sex hormone 17β-estradiol (E2) inhibits experimental arthritis. γδT cells are significant producers of IL-17, thus the aim of this study was to investigate if E2 influenced
Tomoki Maekawa et al.
Nature communications, 6, 8272-8272 (2015-09-17)
Del-1 is an endothelial cell-secreted anti-inflammatory protein. In humans and mice, Del-1 expression is inversely related to that of IL-17, which inhibits Del-1 through hitherto unidentified mechanism(s). Here we show that IL-17 downregulates human endothelial cell expression of Del-1 by
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