I3525
Interleukin-17A human
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinónimos:
CTLA-8, IL-17
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About This Item
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in E. coli
Ensayo
≥98% (SDS-PAGE)
Formulario
lyophilized powder
potencia
≤2.0 ng/mL ED50
mol peso
31 kDa
envase
pkg of 50 μg
técnicas
cell culture | mammalian: suitable
impurezas
endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... IL17A(3605)
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Acciones bioquímicas o fisiológicas
IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
Initially known as CTLA-8; is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system; has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
Forma física
Lyophilized with no additives.
Nota de análisis
- The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
- Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Yan Jin et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 52(10), 981-988 (2015-08-25)
There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time. This work aims to present a clearer relationship between asthma and the polymorphisms of IL-17A and IL-17F. Searches
Lin Fan et al.
PloS one, 10(5), e0127087-e0127087 (2015-05-29)
Th1 cells play an essential role in immune protection against tuberculosis. Th17 cells might be involved with immune pathology in active human tuberculosis (TB). The balance between Th1 and Th17 cells in patients with cavitary tuberculosis needs to be clarified
W T Qi et al.
Genetics and molecular research : GMR, 14(4), 13364-13369 (2015-11-05)
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were
J Y Wang et al.
Allergy, 64(7), 1056-1060 (2009-02-13)
The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of
Thomas Fabre et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3925-3933 (2014-09-12)
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have
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