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Key Documents

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I2784

Sigma-Aldrich

INH2BP

≥98% (HPLC), solid

Sinónimos:

5-Iodo-6-amino-1,2-benzopyrone

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About This Item

Fórmula empírica (notación de Hill):
C9H6INO2
Número de CAS:
137881-27-7
Peso molecular:
287.05
MDL number:
MFCD00912555
UNSPSC Code:
12352202
PubChem Substance ID:
24724511

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 31 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Nc1ccc2OC(=O)C=Cc2c1I

InChI

1S/C9H6INO2/c10-9-5-1-4-8(12)13-7(5)3-2-6(9)11/h1-4H,11H2

InChI key

WWRAFPGUBABZSD-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1); anti-apoptotic.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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France Vaillancourt et al.
Arthritis research & therapy, 10(5), R107-R107 (2008-09-11)
4-Hydroxynonenal (HNE) is one of the most abundant and reactive aldehydes of lipid peroxidation products and exerts various effects on intracellular and extracellular signalling cascades. We have previously shown that HNE at low concentrations could be considered as an important
J G Mabley et al.
British journal of pharmacology, 133(6), 909-919 (2001-07-17)
Activation of poly(ADP-ribose) synthetase (PARS, also termed polyADP-ribose polymerase or PARP) has been proposed as a major mechanism contributing to beta-cell destruction in type I diabetes. In the present study, we have investigated the role of PARS in mediating the
Raquel M Forsythe et al.
Shock (Augusta, Ga.), 17(3), 180-184 (2002-03-20)
Studies indicate that endotoxin (LPS) causes intestinal injury, increases inducible nitric oxide synthase (iNOS) activity, leads to increased NO production, and promotes bacterial translocation (BT). To investigate the mechanism by which LPS causes gut injury and to test the hypothesis
C Szabó et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(7), 3867-3872 (1998-05-09)
Peroxynitrite, a cytotoxic oxidant formed from nitric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly(ADP-ribose) synthase (PARS; EC 2.4.2.30). The cellular function of PARS was determined in fibroblast lines from PARS knockout animals (PARS-/-)
Lina Du et al.
The Journal of biological chemistry, 278(20), 18426-18433 (2003-03-11)
Poly(ADP-ribosylation), primarily via poly(ADP-ribose) polymerase-1 (PARP-1), is a pluripotent cellular process important for maintenance of genomic integrity and RNA transcription in cells. However, during conditions of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mitochondrial failure and cell death.
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