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Key Documents

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I0782

Sigma-Aldrich

Imazodan

≥99% (HPLC)

Sinónimos:

4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914

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About This Item

Fórmula empírica (notación de Hill):
C13H12N4O
Número de CAS:
84243-58-3
Peso molecular:
240.26
MDL number:
MFCD00867109
UNSPSC Code:
41106305
PubChem Substance ID:
24278485

assay

≥99% (HPLC)

color

yellow, powder

solubility

DMSO: 50 mg/mL, clear, yellow

SMILES string

O=C1CCC(=NN1)c2ccc(cc2)-n3ccnc3

InChI

1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)

InChI key

VXMYWVMXSWJFCV-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

Biochem/physiol Actions

Selective phoshodiesterase III (PDE3) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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R E Weishaar et al.
Journal of cyclic nucleotide and protein phosphorylation research, 11(7), 513-527 (1986-01-01)
Two approaches were taken to examine the role which the different forms of phosphodiesterase present in cardiac muscle play in regulating contractility. In an initial study, the effect of selective inhibitors of i) the calmodulin-stimulated phosphodiesterase (M & B 22
J A Allert et al.
Journal of cardiovascular pharmacology, 16(1), 59-67 (1990-07-01)
Although recent studies indicate that MCI-154 exerts novel positive inotropic actions in heart muscle, the chronotropic properties of this new drug remain undefined. The present study compared the inotropic/chronotropic profile of MCI-154 with those of a nonselective beta 1/beta 2-agonist
R P Steffen et al.
Journal of cardiovascular pharmacology, 8(3), 520-526 (1986-05-01)
The purpose of this study was to evaluate the effect of the new cardiotonic, imazodan (CI-914), on myocardial hemodynamics and oxygen consumption, and peripheral blood flow distribution. Organ blood flow was measured by the radiolabeled-microsphere-reference-withdrawal technique and myocardial oxygen consumption
High-performance liquid chromatographic assay of imazodan, methylparaben and propylparaben in imazodan injection.
T Geria et al.
Journal of chromatography, 450(3), 407-413 (1988-10-26)
S E Sadler
Molecular endocrinology (Baltimore, Md.), 5(12), 1947-1954 (1991-12-01)
Insulin-like growth factor-I (IGF-I) stimulated Xenopus laevis oocyte ribosomal S6 kinase activity 5- to 10-fold, with an apparent EC50 of 0.8 +/- 0.1 nM after 90 min of hormone treatment. IGF-I-stimulated enzyme activity was inhibited by treatment of oocytes with
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