This product has not been tested to determine the molecular weight. However, historical information indicates a range of 1.6 - 2 MDa. Currently, there is no product available at a molecular weight of 100-200 kDa. Product H7630, from bovine vitreous humor, has historically demonstrated a molecular weight of approximately 300 kDa. Please see the link below to review this product:
https://www.sigmaaldrich.com/product/sigma/h7630
H5388
Hyaluronic acid sodium salt from rooster comb
avian glycosaminoglycan polysaccharide
Sinónimos:
Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
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100 MG
MXP 3,471.00
250 MG
MXP 7,181.00
1 G
MXP 17,099.00
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100 MG
MXP 3,471.00
250 MG
MXP 7,181.00
1 G
MXP 17,099.00
About This Item
Número de CAS:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
Productos recomendados
biological source
chicken (rooster comb)
Quality Level
form
powder
impurities
≤2% protein (Lowry)
color
white
solubility
water: ~5 g/L
cation traces
Na: 3-7%
storage temp.
−20°C
SMILES string
[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
InChI
1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key
YWIVKILSMZOHHF-QJZPQSOGSA-N
Application
Biochem/physiol Actions
High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.
Hyaluronic acid is a polysaccharide present in the skin, connective tissue, vitreous humor and synovial fluid. It is essential for tissue hydration and functions to regenerate skin post injury or wounds.[4] Hyaluronic acid, apart from having dermatologic and ophthalmologic applications, serves as a drug delivery vehicle.[5] Hyaluronic acid also exhibits antioxidant and antiglycation properties.[6]
Other Notes
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Purification and characterization of hyaluronic acid from chicken combs
Rosa CS, et al.
Ciencia Rural, 42(9), 1682-1687 (2012)
Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity
Ramakrishna S, et al.
PLoS ONE, 7(5), e37772-e37772 (2012)
Extraction, purification and characterization of hyaluronic acid from Rooster comb
Kulkarni SS, et al.
Journal of Applied and Natural Science, 10(1), 313-315 (2018)
Ya-li Yang et al.
Biophysical journal, 96(4), 1566-1585 (2009-02-17)
In this work, the gelation of three-dimensional collagen and collagen/hyaluronan (HA) composites is studied by time sweep rheology and time lapse confocal reflectance microscopy (CRM). To investigate the complementary nature of these techniques, first collagen gel formation is investigated at
Hyaluronic acid enhances gene delivery into the cochlea
Shibata SB, et al.
Human Gene Therapy, 23(3), 302-310 (2011)
Artículos
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
Protocolos
To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.
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Mol Wt of H5388 (CAS Number 9067-32-7) Please share the Sodium Hyaluronate (g quantity) I am looking for Mol.Wt 100-200 Kda
1 answer-
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What is the purity of Hyaluronic acid, Product H5388?
1 answer-
Sigma does not perform purity testing on this product due to the variable molecular weight and degradation that may occur in native glycosaminoglycans. This product is tested for activity and protein content which provide information regarding impurities and suitability.
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What is the solubility of Hyaluronic acid, Product H5388?
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For Sigma's analytical test, 15 mg of this product is dissolved in 5 mL of 0.3 M phosphate buffer, pH 5.35 at 25°C (i.e., 3 mg/mL).
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What is the molecular weight of Hyaluronic acid, Product H5388?
1 answer-
Product No. H5388 is a linear heteropolysaccharide with repeating 3-O-(β-D-glucuronido)-N-acetyl-D-glucosamine units linked by β-(1-->4)) hexosaminidic bonds. The molecular weight of this subunit has not been determined, but could be calculated from the information above. Molecular weights of hyaluronic acids vary from 0.1-10 million, depending on the source. The hyaluronic acid from rooster comb is expected to have a molecular weight of 1-4 million.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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