GW22689B
Anti-MMP12 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
origen biológico
chicken
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
human
técnicas
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... MMP12(4321)
Descripción general
MMP12 (matrix metalloproteinase 12) is a member of the MMP protein family and is localized to human chromosome 11q22.2-22.3. It is made of nine introns and ten exons, and spans 13kb. It is expressed in a very narrow range of human tissues, and assay of multiple normal human tissues showed its mRNA expression only in placenta. It is found to be expressed in alveolar macrophages of cigarette smokers. It is also called macrophage metalloelastase, and is produced in an inactive form of 54kDa. It is cleaved into an active form of 45kDa, which if further cleaved into 22kDa form. Predominantly, it acts on elastin, and can also degrade fibronectin, laminin, vitronectin etc.
Inmunógeno
Immunogen Sequence: GI # 4505207, sequence 107-470
Recombinant matrix metalloproteinase 12 preproprotein
Aplicación
Anti-MMP12 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Acciones bioquímicas o fisiológicas
Matrix metalloproteinase-12 (MMP-12) may act as a specific marker of Stanford-A acute aortic dissection (AAD). The gene is expressed in the primary tumor and acts as a molecular marker that may be useful for predicting extracapsular spread (ECS) in head and neck squamous cell carcinomas (HNSCC) patients with metastatic nodal disease. It may be associated with asthma through inappropriate attraction of leukocytes to the inflamed tissue. It may also serve as a potential diagnostic tool and a therapeutic target in vascular injury and repair.
Forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
¿No encuentra el producto adecuado?
Pruebe nuestro Herramienta de selección de productos.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
¿No ve la versión correcta?
Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Maria Proietta et al.
Annals of medicine, 46(1), 44-48 (2014-01-18)
The study evaluated macrophage cytokines and macrophage metalloprotease (MMP)-12 levels in patients with Stanford-A acute aortic dissection (AAD) and in patients with critical carotid artery stenosis (CAS) compared with patients matched for age, sex, and traditional cardiovascular risk factors (RF).
Fumiya Yamaide et al.
International archives of allergy and immunology, 160(3), 287-296 (2012-10-19)
Matrix metalloproteinase 12 gene (MMP12) has been shown to be associated with asthma in a Caucasian population. In this study, we investigate whether single-nucleotide polymorphisms (SNPs) of MMP12 are associated with a risk for asthma in a Japanese population. We
Jin Man Kim et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 270(3), 1137-1142 (2012-08-22)
Matrix metalloproteinases (MMPs) play an important role in tumor invasiveness and metastasis. The aim of this study was to investigate the expression pattern of MMPs in the primary tumor of head and neck squamous cell carcinomas (HNSCC) with cervical node
Yi Song et al.
BMC cardiovascular disorders, 13, 34-34 (2013-05-07)
Aortic dissection(AD) is an acute process of large blood vessels characterized by dangerous pathogenic conditions and high disability and high mortality. The pathogenesis of AD remains debated. Matrix metalloproteinase-12 (MMP-12) participates in many pathological processes such as abdominal aortic aneurysm
A Belaaouaj et al.
The Journal of biological chemistry, 270(24), 14568-14575 (1995-06-16)
Human macrophage metalloelastase (HME) is a recent addition to the matrix metalloproteinase (MMP) family that was initially found to be expressed in alveolar macrophages of cigarette smokers. To understand more about HME expression, analysis of the structure and location of
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico