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Merck

GW21230

Sigma-Aldrich

Anti-NKAP antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-NF-kappaB activating protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21230

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NKAP(79576)

Immunogen

Immunogen Sequence: GI # 13375676, sequence 110-170
Recombinant NF-kappaB activating protein

Application

Anti-NKAP antibody produced in chicken is suitable for western blottinganalysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

NF-κ-B-activating protein is a protein encoded by the NKAP gene in humans. It is a novel nuclear regulator of TNF- and IL-1-induced NF-κB activation. NKAP is associated with the histone deacetylase HDAC3 and is found to be a part of DNA-binding complex. It is associated with the Notch corepressor complex. NKAP functions as a transcriptional repressor, acts on Notch target genes and is essential for αβ T cell development. It is also required for T cell maturation and the acquisition of functional competency.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Eriko Fukuda et al.
Genes to cells : devoted to molecular & cellular mechanisms, 26(3), 180-189 (2021-02-03)
TRA98 is a rat monoclonal antibody (mAb) which recognizes a specific antigen in the nuclei of germ cells. mAb TRA98 has been used to understand the mechanism of germ cell development and differentiation in many studies. In mice, the antigen
Anthony G Pajerowski et al.
Immunity, 30(5), 696-707 (2009-05-05)
T cell development depends on the coordinated interplay between receptor signaling and transcriptional regulation. Through a genetic complementation screen a transcriptional repressor, NKAP, was identified. NKAP associated with the histone deacetylase HDAC3 and was shown to be part of a
Danying Chen et al.
Biochemical and biophysical research communications, 310(3), 720-724 (2003-10-11)
Receptor-interacting protein (RIP) is a serine/threonine protein kinase that is critically involved in tumor necrosis factor receptor-1 (TNF-R1)-induced NF-kappaB activation. In a yeast two-hybrid screening for potential RIP-interacting proteins, we identified a novel protein designated as NKAP. Although NKAP interacts
Fan-Chi Hsu et al.
The Journal of experimental medicine, 208(6), 1291-1304 (2011-06-01)
Newly generated T cells are unable to respond to antigen/MHC. Rather, post-selection single-positive thymocytes must undergo T cell maturation to gain functional competency and enter the long-lived naive peripheral T cell pool. This process is poorly understood, as no gene

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