G8415

L-Glutamic acid

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

• Sinónimos: (S)-2-Aminopentanedioic acid, Glu
• Fórmula lineal: HO₂CCH₂CH₂CH(NH₂)CO₂H
• Número de CAS: 56-86-0
• Peso molecular: 147.13
• Beilstein: 1723801
• Número CE: 200-293-7
• Número MDL: MFCD00002634
• Código UNSPSC: 12352209
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24895340
• NACRES: NA.26

Propiedades

• Nombre del producto: L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
• origen biológico: non-animal source
• Nivel de calidad: 300
• Agency: meets EP testing specifications
• Ensayo: 98.5-100.5%
• Formulario: powder
• técnicas: cell culture | mammalian: suitable
• impurezas: endotoxin, tested
• color: white
• mp: 205 °C (dec.) (lit.)
• solubilidad: 1 M HCl: 100 mg/mL
• densidad: 1.54 g/cm³ at 20 °C
• trazas de anión: chloride (Cl^-): ≤200 ppm; sulfate (SO₄^2-): ≤200 ppm
• trazas de catión: As: ≤1 ppm, passes test; Fe: ≤10 ppm, passes test; NH₄⁺: ≤200 ppm, passes test
• aplicaciones: pharmaceutical (small molecule)
• cadena SMILES: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• Clave InChI: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Información sobre el gen: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Descripción

Aplicación

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.[1][2][3]

Acciones bioquímicas o fisiológicas

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid.[4] Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity.[5] It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids.[5][6] In cells, glutamine is converted to glutamate by the enzyme glutaminase.[6] Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.[5]

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)