G1920
Anti-Glutamate Receptor 7, Metabotropic antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-mGluR7
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About This Item
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
human
disponibilidad
not available in Japan
técnicas
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using human brain, neurons
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... GRM7(2917)
mouse ... Grm7(108073)
rat ... Grm7(81672)
Descripción general
The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.
Inmunógeno
synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 7, conjugate to KLH. The immunizing peptide has 100% homology with the rat gene and 95% homology with the mouse gene.
Aplicación
Anti-Glutamate Receptor 7, Metabotropic antibody produced in rabbit is suitable for immunohistochemistry using formalin-fixed, paraffin-embedded sections of human brain, neurons.
Acciones bioquímicas o fisiológicas
Glutamate Receptor 7 belongs to group III and inhibits adenyl cyclase. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Activation of Group III receptors has been shown to be neuroprotective. Glutamate receptors are important mediators of excitatory amino acid neurotransmission.
Forma física
Solution in phosphate buffered saline, containing 0.1% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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A I Faden et al.
Journal of neurotrauma, 14(12), 885-895 (1998-02-25)
We have used an in vitro trauma model to examine the effects of modulation of group III metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat cortical neuronal/glial cultures were subjected to standardized mechanical injury using a punch that
V Bruno et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(17), 6413-6420 (2000-08-31)
Activation of group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, and mGluR8) has been established to be neuroprotective in vitro and in vivo. To disclose the identity of the receptor subtype(s) that exert(s) the protective effect, we have used group
W Spooren et al.
Behavioural pharmacology, 14(4), 257-277 (2003-07-03)
Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed
J P Pin et al.
Neuropharmacology, 34(1), 1-26 (1995-01-01)
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to
Domenico E Pellegrini-Giampietro
Trends in pharmacological sciences, 24(9), 461-470 (2003-09-12)
Metabotropic glutamate receptors of the mGlu(1) and mGlu(5) subtypes exhibit a high degree of sequence homology and are both coupled to phospholipase C and intracellular Ca(2+) mobilization. However, functional differences have been detected for these receptor subtypes when they are
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