G137

(2S,4R)-4-Methylglutamic acid

solid

• Sinónimos: SYM-2081
• Fórmula empírica (notación de Hill): C₆H₁₁NO₄
• Número de CAS: 31137-74-3
• Peso molecular: 161.16
• MDL number: MFCD00937765
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895059

Propiedades

• form: solid
• optical activity: [α]23/D +23.2°, c = 0.73 in 6 M HCl(lit.)
• color: white
• solubility: H₂O: >10 mg/mL
• SMILES string: C[C@H](C[C@H](N)C(O)=O)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
• InChI key: KRKRAOXTGDJWNI-DMTCNVIQSA-N
• Gene Information: human ... GRIK1(2897) , GRIK2(2898) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409) , Slc1a2(29482)

Descripción

Application

(2S,4R)-4-Methylglutamic acid has been used as a kainate receptor (KAR) antagonist to test its effect on acetylcholine release in muscle cells.

Biochem/physiol Actions

(2S,4R)-4-Methylglutamic acid (SYM 2081) is a selective antagonist for the kainate receptor that elicits antihyperalgesic and antinociceptive functionality. It may be useful to treat mechanical allodynia associated with the cold-freeze injury model. SYM 2081 also mediates the suppression of glutamate release from injured C-fibers. It may also be involved in the attenuation of heat hyperalgesia in nerve injury models.

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)